T e = (T p x T b) / (T p + T b) or simply 1/T e = 1/T p+1/T b The time interval required for the radioactivity of a certain amount of radioactive substance distributed in tissues and organs to decrease to half its original value due to radioactive decay and biological elimination. T b is affected by many external factors such as hydration, hepatic function and renal function. The time interval required for the body to eliminate 50% of any substance by normal routes of elimination: metabolic turnover and excretion. T p is always a constant for a particular radioactive isotope and is unaffected by changes in surrounding such as temperature or pressure. The time interval required for an amount of certain radioactive nuclei to decay to half of its original value. The half-life time is the duration it takes for any physical process to reduce the initial amount to fifty percent of its initial value.
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